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  7. Hydroxychloroquine sulfate, 98%

Hydroxychloroquine sulfate, 98%

Product Code. 10646271 Shop All Thermo Scientific Chemicals Products
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Product Code. 10646271 Supplier Thermo Scientific Acros Supplier No. 263010250
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Description

Hydroxychloroquine sulfate, CAS # 747-36-4, is a chemical compound with antiparasitic, antiviral, and anti-rheumatic activities. | CAS: 747-36-4 | C18H26ClN3O·H2SO4 | 433.96 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Hydroxychloroquine sulfate shows antimalarial activity against malaria parasites mainly in the intra-erythrocytic phase of its life cycle. It acts by inhibiting the heme polymerase inside the food vacuole of the parasites
  • It shows an inhibitory activity in autophagy preventing the lysosome fusion with the autophagosome
  • Some studies demonstrated that hydroxychloroquine sulfate, due to its antiviral activity can restrict HIV infection in vitro

Applications

  • Hydroxychloroquine sulfate displays antiviral and anti-rheumatic activities
  • In vitro and in vivo experiments have been performed to investigate the role of hydroxychloroquine sulfate in the treatment of SARS-CoV-2 disease
  • Hydroxychloroquine sulfate can be used in immunofluorescence assays to evaluate the antiviral mechanisms in dengue virus-2 infection. In this disease, this compound can activate the innate immune response
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 747-36-4
Molecular Formula C18H26ClN3O·H2SO4
Molecular Weight (g/mol) 433.96
MDL Number MFCD00078203
InChI Key JCBIVZZPXRZKTI-UHFFFAOYSA-N
Synonym hydroxychloroquine sulfate, hydroxychloroquine sulphate, ercoquin, plaquinol, toremonil, 2-4-7-chloroquinolin-4-yl amino pentyl ethyl amino ethanol sulfate, hydroxychloroquine sulfate usp, plaquenil tn, hydroxychloroquine; sulfuric acid, dsstox_cid_27788
PubChem CID 12947
IUPAC Name 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid
SMILES CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O

Specifications

Melting Point 240.0°C
Color White
Loss on Drying 2% max. (105°C, 2 hrs.)
Infrared Spectrum Authentic
Assay Percent Range 0.98
Packaging Glass bottle
Quantity 25 g
Merck Index 15, 4857
Solubility Information Solubility in water: soluble. Other solubilities: practically insoluble in alcohol,chloroform,,ether,acetone and acetic acid
Formula Weight 433.96
Percent Purity 98%
Physical Form Crystalline Powder
Chemical Name or Material Hydroxychloroquine sulfate
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Safety and Handling

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Product Identifier
  • Hydroxychloroquine sulfate
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
  • Skin corrosion/irritation Category 2
 Hazard Statement
  • H302-Harmful if swallowed.
  • H319-Causes serious eye irritation.
 Precautionary Statement
  • P264-Wash face, hands and anyexposed skin thoroughly after handling.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
  • P337+P313-If eye irritation persists: Get medical advice/attention.
 Supplemental information
  • MIXTURE LIST-Contains : Hydroxychloroquine sulphate
SDS

RUO – Research Use Only

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