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Gibco™ Human TL-1A, Animal-Free Recombinant Protein, PeproTech®

Product Code. 17896458
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Quantity:
250 μg
5 μg
Unit Size:
250µg
5µg
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17896458 5 μg 5µg
17836458 250 μg 250µg
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Product Code. 17896458 Supplier Gibco™ Supplier No. AF310235UG

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Description

Recombinant Protein

Recombinant Human TL-1A is a 22.1 kDa polypeptide of 195 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O95150
For Use With (Application) Functional Assay
Format Lyophilized
Formulation protein with no preservative
Gene ID (Entrez) 9966
Molecular Weight (g/mol) 22.1 kDa
Name Human TL-1 A, Animal-Free
Purification Method HPLC, SDS-PAGE
Quantity 5 μg
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/ μg
Gene Alias bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15); MGC129934; MGC129935; TL1; TL1A; TNF ligand-related molecule 1; TNF superfamily ligand TL1A; TNFSF15; TNLG1B; tumor necrosis factor (ligand) superfamily member 15; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand 1 B; tumor necrosis factor ligand superfamily member 15; Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form; tumor necrosis factor superfamily member 15; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor; vascular endothelial growth inhibitor-192 A; Vegi; VEGI192A
Common Name TL1A
Gene Symbol TNFSF15
Biological Activity Determined by its ability to stimulate IFN-gamma production by human PBMC co-stimulated with Human IL-12 and Human IL-18.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence MQLRAQGEAS VQFQALKGQE FAPSHQQVYA PLRADGDKPR AHLTVVRQTP TQHFKNQFPA LHWEHELGLA FTKNRMNYTN KFLLIPESGD YFIYSQVTFR GMTSECSEIR QAGRPNKPDS ITVVITKVTD SYPEPTQLLM GTKSVCEVGS NWFQPIYLGA MFSLQEGDKL MVNVSDISLV DYTKEDKTFF GAFLL
Content And Storage -20°C
Activity Determined by its ability to stimulate IFN-gamma production by human PBMC co-stimulated with Human IL-12 and Human IL-18.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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