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STEMCELL Technologies Human Recombinant EGFR

Product Code. 17119751
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Quantity:
50 μg
Unit Size:
50µg
This item is not returnable. View return policy

Product Code. 17119751

Brand: STEMCELL Technologies 78171.1

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This item is not returnable. View return policy

Description

Epidermal growth factor receptor

  • Epidermal growth factor receptor (EGFR) is a type I transmembrane protein and receptor tyrosine kinase
  • EGFR has been shown to bind to some members of the EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, epiregulin, heparin-binding EGF, and neuregulin-2α
  • EGFR ligand binding induces homodimerization, as well as heterodimerization of EGFR with ErbB2 or with ligand-activated ErbB3 or ErbB4 (Schlessinger)
  • Dimerization results in kinase activation, phosphorylation, and cell signaling, mediated primarily through MEK/ERF and AKT pathways (Navlonic et al.) EGFR signaling has been shown to regulate cell proliferation, differentiation, motility, and apoptosis
  • Elevated levels of EGFR have been correlated with carcinogenesis (Maihle et al.) Protein contains a His-residue tag at the carboxyl end of the polypeptide chain

Specifications

Name Avian erythroblastic leukemia viral oncogene homolog, Epidermal growth factor receptor, Erb-b2 receptor tyrosine kinase 1, ERBB1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, v-erb-b
Quantity 50 μg
Cell Type Brain Tumor Stem Cells; Endoderm, PSC-Derived; Hematopoietic Stem and Progenitor Cells; Mesenchymal Stem and Progenitor Cells; Mesoderm, PSC-Derived; Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Neurons; Pluripotent Stem Cells; Prostate Cells
Purity or Quality Grade ≥95%
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