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Gibco™ Human/Mouse/Rat Myostatin Recombinant Protein, PeproTech®

Product Code. 17819892
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Product Code. Quantity unitSize
17819892 500 μg 500µg
17840463 100 μg 100µg
17850263 10 μg 10µg
17841223 1 mg 1mg
17861133 250 μg 250µg
17831423 2 μg 2µg
17890353 50 μg 50µg
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Product Code. 17819892

Brand: Gibco™ 12000500UG

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Description

Recombinant Protein

The amino acid sequence of mature myostatin is extremely conserved across species, and is the same in murine, rat, chicken, turkey, porcine, and human. Myostatin is expressed as the C-terminal part of a precursor polypeptide, which also contains a short N-terminal signal sequence for secretion, and a propeptide of 243 amino acids. After dimerization of this precursor, the covalent bonds between the propeptide and the mature ligand are cleaved by furin-type proteases. However, the resulting two proteins remain associated through non-covalent interactions, and are secreted as a latent complex. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O08689, O14793, O35312
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 17700, 2660, 29152
Molecular Weight (g/mol) 25 kDa
Name Human/Mouse/Rat Myostatin
Quantity 500 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias Cmpt; compact; Gdf8; GDF-8; growth differentiation factor 8; growth/differentiation factor 8; H-Myo-Propeptide; H-Myostatin; MSLHP; MSTN; Myostatin
Common Name Myostatin
Gene Symbol Mstn
Biological Activity Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml
Conjugate Unconjugated
Recombinant Recombinant
Sequence DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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