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Gibco™ Human IGF-BP3, Animal-Free Recombinant Protein, PeproTech®

Product Code. 17843783
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17843783 100 μg 100µg
17823773 1 mg 1mg
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17823503 500 μg 500µg
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Product Code. 17843783 Supplier Gibco™ Supplier No. AF10008100UG

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Description

Recombinant Protein

Recombinant Human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IGFBP3 is a gene that belongs to the insulin-like growth factor binding protein (IGFBP) family. The gene encodes a protein that contains both an IGFBP domain and a thyroglobulin type-I domain. This protein is known to form a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. The complex circulates in the plasma and prolongs the half-life of IGFs while also altering their interaction with cell surface receptors. Various isoforms of the gene have been identified through alternate transcriptional splice variants. Diseases associated with IGFBP3 include Insulin-Like Growth Factor I and Acid-Labile Subunit Deficiency.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P17936
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 3486
Molecular Weight (g/mol) 28.8 kDa
Name Human IGF-BP3, Animal-Free
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/ μg
Gene Alias acid stable subunit of the 140 K IGF complex; AI649005; binding protein 29; binding protein 53; BP53; BP-53; Growth hormone dependent binding protein; growth hormone-dependent binding protein; I79_011450; IBP3; IBP-3; IGF binding protein 3; IGF-binding protein 3; IGFBP; Igfbp3; IGF-BP3; IGFBP-3; IGgfbp3; Insulin like growth factor binding protein; insulin like growth factor binding protein 3; insulin-like growth factor binding protein 3; Insulin-like growth factor binding protein 3 precursor; insulin-like growth factor-binding protein (IGF-BP3); insulin-like growth factor-binding protein 3; tcag7.703
Common Name IGFBP3
Gene Symbol IGFBP3
Biological Activity Determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 is ≤ 0.2 ug/ml in the presence of 15 ng/ml of human IGF-II.
Conjugate Unconjugated
Recombinant Recombinant
Sequence GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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