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ACROBiosystems Human GM-CSF R alpha Protein, Fc Tag

Product Code. 16407619
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
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16407619 100 μg 100µg
16417619 1 mg 1mg
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Product Code. 16407619 Supplier ACROBiosystems Supplier No. GRAH5255100ug

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Description

GM-CSF R alpha(Granulocyte-macrophage colony-stimulating factor receptor subunit alpha) is also known as CSF2RA, CD116, GMR-alpha. Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder of pulmonary surfactant accumulation and hypoxemic respiratory failure caused by mutations in CSF2RA (encoding the granulocyte/macrophage colony-stimulating factor [GM-CSF] receptor α-chain [CD116]), which results in reduced GM-CSF-dependent pulmonary surfactant clearance by alveolar macrophages.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.9 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Accession Number NP_006131.2
Molecular Weight (g/mol) 60.9 kDa
Quantity 100 μg
Source Human GM-CSF R alpha, Fc Tag (GRA-H5255) is expressed from human 293 cells (HEK293). It contains AA Glu 23 - Gly 320 (Accession # P15509-1).
Immunogen Glu 23 - Gly 320
Storage Requirements -20°C
Gene Alias GM-CSF R alpha,GM-CSF-R-alpha,GMCSFR-alpha,GMR-alpha,CSF2RA,CSF2R,CSF2RY,CDw116,CD116
Common Name GM-CSF R alpha
Conjugate Unconjugated
Species Human
Protein Tag Fc Tag
Buffer Tris with Glycine, Arginine and NaCl, pH7.5
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype Other Recombinant Proteins
Purity or Quality Grade >95% as determined by SDS-PAGE
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