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Invitrogen™ Human DACT3 Synthetic Peptide

Product Code. 15328970
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Quantity:
50 μg
Unit Size:
50µg
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15328970 50 μg 50µg
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For Research Use Only. All usage must comply with product instructions.
Product Code. 15328970 Supplier Invitrogen™ Supplier No. PEP0750
 Restricted Item
Estimated Shipment: 21-08-2026
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For Research Use Only. All usage must comply with product instructions.

Description

Synthetic Peptide

This peptide corresponds to 17 amino acids near the amino terminus of human Dact3. PEP-0750 can be used as a blocking peptide with polyclonal antibody PA5-20630.

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/beta-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Gene ID (Entrez) 147906
Species Human
Purification Method purified
Accession Number Q96B18
Common Name DACT3
Concentration 200 μg/mL
Content And Storage -20°C
Description Synthetic Peptide
Format Liquid
Formulation PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
For Use With (Application) Blocking Assay, Control
Gene Alias Antagonist of beta-catenin Dapper homolog 3; arginine-rich region 1 protein; dact 3; Dact3; Dapper antagonist of catenin 3; dapper homolog 3; dapper homolog 3, antagonist of beta-catenin (xenopus); dapper, antagonist of beta-catenin, homolog 3; DAPPER3; dishevelled binding antagonist of beta catenin 3; dishevelled-binding antagonist of beta-catenin 3; EG666671; naa-3; RGD1563892; RRR1
Gene Symbol DACT3
Lyophilized No
Preservative Sodium azide
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO
Storage Buffer PBS
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