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Invitrogen™ HOXA11 Polyclonal Antibody
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Product Code. 17208153 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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17208153 100 μL 100µL
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Product Code. 17208153 Supplier Invitrogen™ Supplier No. PA5115376

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total HOXA11.

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t (10:14) (q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HOXA11
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene HOXA11
Gene Accession No. P31270, P31311
Gene Alias homeo box 1I; homeo box A11; homeobox A11; homeobox protein Hox-1.9; Homeobox protein Hox-1I; homeobox protein HOXA11; homeobox protein Hox-A11; HOX1; Hox-1.9; HOX11; HOX1I; Hoxa11; Hoxa-11; NEWGENE_1564605; RUSAT1
Gene Symbols HOXA11
Host Species Rabbit
Immunogen A synthesized peptide derived from human HOXA11(Accession P31270), corresponding to amino acid residues P137-P187.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 103692131, 15396, 3207
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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