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Invitrogen™ HEXB Polyclonal Antibody
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Product Code. 15751012 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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15751012 100 μL 100µL
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Product Code. 15751012 Supplier Invitrogen™ Supplier No. PA563236

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FGFYKWHHEP AEFQAKTQVQ QLLVSITLQS ECDAFPNISS DESYTLLVKE PVAVLKANRV W Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 69%.

Hexosaminidase B (HEXB), also designated beta-hexosaminidase B, is a Hexosaminidase B (HEXB), also designated b-hexosaminidase B, is a tetramer of two b-A and two b-B chains and is found in the lysosomes of cells. Sandhoff disease (SD), also known as GM2-gangliosidosis type II, is caused by mutations in the HEXB gene that affect the b subunit. These mutations disrupt the activity of HEXB and HEXA, which prevents the breakdown of GM2 ganglioside, a fatty material found in the brain, therby rendering both the HEXA and HEXB enzymes deficient. SD is a rare autosomal recessive disorder characterized by an accumulation of GM2 ganglioside, which causes progressive destruction of the central nervous system. Sandhoff disease is similar to Tay-Sachs disease, which is caused by mutations in the HEXA gene, although SD is more severe.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HEXB
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Hexb
Gene Accession No. P07686
Gene Alias beta-hexosaminidase subunit beta; Beta-hexosaminidase subunit beta chain A; Beta-hexosaminidase subunit beta chain B; Beta-N-acetylhexosaminidase subunit beta; cervical cancer proto-oncogene 7 protein; ENC-1AS; epididymis luminal protein 248; epididymis secretory protein Li 111; HCC7; HCC-7; HEL-248; HEL-S-111; HEXB; hexosaminidase B; hexosaminidase B (beta polypeptide); hexosaminidase subunit B; hexosaminidase subunit beta; N-acetyl-beta-glucosaminidase subunit beta
Gene Symbols Hexb
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human HEXB. Recombinant protein control fragment (Product #RP-100907).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3074
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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