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Invitrogen™ H1FOO Polyclonal Antibody
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Product Code. 16611005 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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16611005 100 μL 100µL
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Product Code. 16611005 Supplier Invitrogen™ Supplier No. PA5104550

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Histone H1.

Eukaryotic Histones are basic and water soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fibers. Two molecules of each of the four core Histones (Histone H2A, H2B, H3, and H4) form the octamer, which consists of two H2A-H2B dimers and two H3-H4 dimers that are nearly symmetrical by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene, that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. H1FOO (H1 histone family, member O, oocyte-specific), also known as OSH1, is a 346 amino acid oocyte-specific Histone that localizes to both the nucleus and the cytoplasm. Expressed as multiple alternatively spliced isoforms, H1FOO is thought to play an important role in gene control during oogenesis and early embryogenesis and is crucial for meiotic maturation of germinal vesicle-stage oocytes.
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Specifications

Antigen H1FOO
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene H1FOO
Gene Accession No. Q8IZA3
Gene Alias C86609; H1 histone family member O, oocyte specific; H1 histone family, member O, oocyte-specific; H1.8; H1fo; H1foo; H1OO; Histone H1oo; oocyte-specific histone H1; Oocyte-specific linker histone H1; OSH1; RGD1566236
Gene Symbols H1FOO
Host Species Rabbit
Immunogen A synthesized peptide derived from human H1FOO(Accession Q8IZA3), corresponding to amino acid residues P137-P187.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 132243, 502875
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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