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  5. Tocris Bioscience™ GW 4064

Tocris Bioscience™ GW 4064

Product Code. 18095942
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50 mg
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18095942 10 mg 10mg
18055562 50 mg 50mg
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Product Code. 18095942 Supplier Tocris Bioscience™ Supplier No. 2473/10

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Description

Selective farnesoid X receptor (FXR) agonist

GW 4064 is a potent and selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM). GW 4064 displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves hyperglycaemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutrient-deprived mouse hepatocytes. GW 4064 protects against lipopolysaccharide (LPS)-induced liver inflammation and apoptosis in mice. GW 4064 reduces Leptin signaling pathway activation in breast cancer cells and inhibits tumor growth in mouse xenografts.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 278779-30-9
Molecular Formula C28H22Cl3NO4

Specifications

Quantity 10 mg
Formula Weight 542.84
Purity >97%
Molecular Weight (g/mol) 542.837
Chemical Name or Material GW 4064
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