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GSK 2193874, Tocris Bioscience™
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Potent and selective TRPV4 antagonist; orally active

Brand:  Tocris Bioscience 5106/5

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Product Code. 15933211

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Description

Description

GSK 2193874 is a potent and selective TRPV4 antagonist (IC50 values are 2 and 40 nM for rat and human receptors, respectively); inhibits Ca2+ influx through TRPV4 channels. Prevents and reverses pulmonary edema after myocardial infarction in vivo models. Selective over a panel of ∽200 human receptors, channels and enzymes. Orally active.
Specifications

Specifications

3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
1336960-13-4
>98%
5 mg
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