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Invitrogen™ GSDMD Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5115330
This item is not returnable.
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Description
Antibody detects endogenous levels of total GSDMD protein, including precursor and the cleaved N-terminal fragment.
GSDMD (gasdermin-D) promotes pyroptosis in response to microbial infection and danger signals. It is produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as, non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, GSDMD moves to the plasma membrane where it strongly binds to inner leaflet lipids including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-biphosphate, phosphatidylinositol (3,4,5)-biphosphate, phosphatidic acid, and phosphatidylserine. GSDMD also exhibits bactericidal activity.
Specifications
| GSDMD | |
| Polyclonal | |
| Unconjugated | |
| GSDMD | |
| 1810036L03Rik; AW558049; DF5L; Dfna5l; FKSG10; gasdermin D; gasdermin domain containing 1; gasdermin domain-containing protein 1; Gasdermin-D; Gasdermin-D, C-terminal; Gasdermin-D, N-terminal; GSDMD; GSDMDC1; GSDMD-CT; GSDMD-NT; M2-4 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 315084, 69146, 79792 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide | |
| P57764, Q9D8T2 | |
| GSDMD | |
| A synthesized peptide derived from human GSDMD(Accession P57764), corresponding to amino acid residues W50-G100. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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