Invitrogen™ GRAMD1A Polyclonal Antibody

Description

Immunogen sequence: SEDEDYVSPL QLNGLGTPKE VGDVIALSDI TSSGAADRSQ EPSPVGSRRG HVTPNLSRAS SDADHGAEED KEEQVDSQPD ASSSQTVTPV AEPPSTEPTQ PDGPTTLGPL DLLPS Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 85%.

Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain. At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER. May play a role in tumor progression. Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). [UniProt].