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GNF-5837, MedChemExpress

Product Code. p-200101502
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Product Code. 16491867

Brand: Medchem Express HY13491

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Description

MedChemExpress GNF-5837 is a potent, selective, and orally bioavailable pan-tropomyosin receptor kinase (TRK) inhibitor which display antiproliferative effects in cellular Ba/F3 assays ( IC50 values of 7 nM, 9 nM and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively) .

GNF-5837 is a potent, selective, and orally bioavailable pan-tropomyosin receptor kinase (TRK) inhibitor which display antiproliferative effects in cellular Ba/F3 assays ( IC50 values of 7 nM, 9 nM and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively) .

Specifications

Chemical Name or Material GNF-5837
CAS 1033769-28-6
Color Orange
Purity Grade Notes Research
Molecular Formula C28H21F4N5O2
Quantity 50 mg
Solubility Information DMSO : ≥ 32 mg/mL (59.76 mM)
SMILES O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C)C(NC3=CC(NC/4=O)=C(C=C3)C4=C\C5=CC=CN5)=C2
Molecular Weight (g/mol) 535.49
Formula Weight 535.49
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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