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  5. Tocris Bioscience™ GLPG 0187

Tocris Bioscience™ GLPG 0187
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Product Code. 18766046
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18766046

Brand: Tocris Bioscience™ 7059/10

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Description

Potent αv integrin inhibitor

GLPG 0187 is a potent αv integrin inhibitor (IC50 values are 1.2-3.7 nM). Inhibits osteoclastic bone resorption and angiogenesis in vitro and in vivo. Suppresses epithelial-mesenchymal transition (EMT) and migration of PC-3M-Pro4/luc cells, without inhibiting cell growth. Induces detachment and necrosis of GL-261 and SMA-560 murine glioma cells.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 3-[[2,5-Dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]-L-alanine
CAS 1320346-97-1
Quantity 10 mg
Target Integrin Receptor Inhibitors
Molecular Formula C29H37N7O5S
Purity 0.97
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