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Gibco™ Human TGF-beta 3 Recombinant Protein

Product Code. 10491795
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Quantity:
5 μg
Unit Size:
Each
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For Research Use Only. All usage must comply with product instructions.

Product Code. 10491795

Brand: Gibco™ PHG9305

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This item is not returnable. View return policy

For Research Use Only. All usage must comply with product instructions.

Description

Recombinant Protein

Purity: >98% by SDS-PAGE and HPLC, Endotoxin Concentration: <0.1 ng/μg, Protein Length: 112 aa (2 identical subunits), Biological Activity: ED50 ≤0.05 ng/mL, Molecular Weight: 17.5 kDa

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P10600
For Use With (Application) Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot
Formulation 0.12% acetic acid with 20% ethanol and no preservative
Gene ID (Entrez) 7043
Molecular Weight (g/mol) 25.4 kDa
Name Human TGF-beta 3
Purification Method Sequential Chromatography
Quantity 5 μg
Source Human
Endotoxin Concentration <0.1 ng/ μg
Gene Alias ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
Common Name TGF beta-3
Biological Activity ED50 ≤ 0.05 ng/mL (≥ 12.5 x 10e6 IU/mg); determined by a toxicity assay using the WHO Standard 98/608 for direct comparison.
Conjugate Unconjugated
Recombinant Recombinant
Sequence Human TGF-beta 3 recombinant protein is a homodimer containing two 112 amino acid subunits
Content And Storage 4°C
Expression System E. coli
Protein Family Growth Factors & Receptors
Form Liquid
Protein Subtype TGFs (Transforming Growth Factors)
Purity or Quality Grade >98% by SDS-PAGE and HPLC
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