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Anti-Human Foxp3 Staining Set APC, eBioscience™

Product Code. 15581075
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Product Code. 15581075 Supplier Invitrogen Supplier No. 77577640

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Description

Includes

  • Fixation/Permeabilization Concentrate (4X) (cat. 00-5123): 30mL, store at 2-8°C. Avoid agitation.
  • Fixation/Permeabilization Diluent (cat. 00-5223): 100mL, store at 2-8°C.
  • Permeabilization Buffer (10X) (cat. 00-8333): 100mL, store at 2-8°C. Note: The 10X Permeabilization Buffer has a natural tendency to precipitate, however, its function is not affected by this. To clarify, the solution can be filtered after dilution to 1x working solution.
  • Normal Rat Serum (cat. 24-5555): 100 μL, store at 2-8°C.
  • Anti-Human Foxp3 APC (clone PCH101, cat. 17-4776): 25 tests, store at 2-8°C. Light-sensitive material.

Antibody Staining Kit

This Anti-Human Foxp3 Staining Set contains the buffers and monoclonal antibody necessary to successfully stain and identify Foxp3+ cells. The PCH101 monoclonal antibody reacts with the amino terminus of human Foxp3, also known as FORKHEAD BOX P3, SCURFIN, and JM2. Foxp3 is a 49-55kDa protein and a member of the forkhead/winged-helix family of transcription factors. It was identified as the gene responsible for the X-linked lymphoproliferative disease observed in scurfy (sf) mice and in the human disorder, X-linked autoimmunity-allergic dysregulation syndrome (XLAAD). Constitutive expression of Foxp3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg), and ectopic expression of Foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells.

The PCH101 antibody crossreacts with rhesus, chimpanzee, and cynomolgus Foxp3. PCH101 recognizes a different epitope of Foxp3 than clones 236A/E7 and 150D/E4.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Foxp3
Applications Flow Cytometry
Classification Monoclonal
Clone PCH101
Conjugate APC
Gene Alias Forkhead Box P3, Scurfin, JM2
Host Species Rat
Quantity 1 kit
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chimpanzee, Cynomolgus, Human, Macaque, Monkey, Non-human Primate, Rhesus Monkey
Content And Storage Store at 2-8°C. Do not freeze. Light sensitive material. Use within 6 months of opening or by date indicated on the bottle.
Isotype IgG2a κ
Product Line eBioscience
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Safety and Handling

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Product Identifier
  • Anti-Human Foxp3 Staining Set APC, eBioscience
 Signal Word
  • Danger
 Hazard Category
  • Carcinogenicity Category 1B
  • Germ cell mutagenicity Category 2
  • Skin sensitiser Category 1
  • Specific target organ toxicity after single exposure Category 1
 Hazard Statement
  • H317-May cause an allergic skin reaction.
  • H341-Suspected of causing genetic defects.
  • H350-May cause cancer.
  • H370-Causes damage to organs.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P260-Do not breathe dust/fume/gas/mist/vapours/spray.
  • P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P264-Wash hands thoroughly after handling.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P308+P311-IF exposed or concerned: Call a POISON CENTER/doctor/.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
  • P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
  • P362+P364-Take off contaminated clothing and wash it before reuse.
  • P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
 Supplemental information
  • MIXTURE LIST-Contain: Formaldehyde, Methanol

For Research Use Only. Not for use in diagnostic procedures.

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