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STEMCELL Technologies FK506

Product Code. 17190332
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Product Code. 17190332 Supplier STEMCELL Technologies Supplier No. 74154

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Description

Calcineurin/NFAT pathway inhibitor; Binds FKBP-12

  • FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.) It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.)
  • Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.)
  • In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.)
  • Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.)

Specifications

CAS 104987-11-3
Synonym Tacrolimus
Quantity 50 mg
Molecular Formula C44H69NO12
Purity ≥99%
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