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Tocris™ Fenoprofen calcium

Product Code. 18749456
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Quantity:
50 mg
Unit Size:
50mg
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Product Code. 18749456

Brand: Tocris™ 6926/50

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Description

Positive allosteric modulator of MC3 receptors; exhibits biased signaling

Fenoprofen calcium is a melanocortin 3 (MC3) receptor positive allosteric modulator (PAM; allosteric enhancer) (pEC50 = 8.69); decreases the EC50 of α-MSH at MC3R. Stimulates ERK1/2 activation at MC3-5R, with highest ERK1/2 activation observed at 3 and 10 μM for MC3R, 1 μM for MC4R, and 3 μM for MC5R. Exhibits biased signaling at MC3-5R, selectively activating ERK1/2 cascade but not canonical cAMP signaling. Antiarthritic.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material α-Methyl-3-phenoxybenzeneacetic acid hemicalcium salt
CAS 34597-40-5
Quantity 50 mg
Molecular Formula C15H13O3.0.5Ca
Formula Weight 261.31
Product Type Positive Allosteric Modulator
Purity 98%
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