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STEMCELL Technologies Everolimus

Product Code. 17180172
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Product Code. 17180172 Supplier STEMCELL Technologies Supplier No. 73122

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Description

mTOR pathway inhibitor; Inhibits FKBP-12

  • Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR)
  • It is a hydroxyethyl ether-substituted derivative of rapamycin with improved pharmacokinetic and pharmacodynamic properties
  • It inhibits both mTORC1 and mTORC2 complexes by binding to FK506-binding protein (FKBP-12), which then binds to mTOR, leading to complex destabilization and blocked kinase function (Zeng et al.; Lebwohl et al.; Sedrani et al.; Huang & Houghton)
  • Inhibits cell proliferation, metabolism, and angiogenesis in a variety of cancers using in vitro and in vivo models (Zhu et al.; Lane et al.; O'Reilly et al.; Lebwohl et al.)
  • Acts as an immunosuppressive agent in the context of organ transplantation (Lebwohl et al.; Wullschleger et al.)

Spécification

CAS 159351-69-6
Synonym RAD001; SDZ-RAD; Xience
Quantity 10 mg
Molecular Formula C53H83NO14
Purity ≥95%
Nom du produit
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