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Etoposide

Product Code. 15495819
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Product Code. 15495819 Supplier Thermo Scientific Alfa Aesar Supplier No. J63651.MB
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Description

Topoisomerase inhibitor and inducer of apoptosis | CAS: 33419-42-0 | C29H32O13 | 588.56 g/mol

Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

Solubility
Insoluble in water.

Notes
Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 33419-42-0
Molecular Formula C29H32O13
Molecular Weight (g/mol) 588.56
MDL Number MFCD00869325,MFCD00869325
InChI Key VJJPUSNTGOMMGY-MRVIYFEKSA-N
Synonym vjjpusntgommgy-nzlmilqcsa
PubChem CID 50936917
IUPAC Name (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one
SMILES COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)C2=CC3=C(OCO3)C=C12

Specifications

Melting Point 236°C to 251°C
Color White
Quantity 25 mg
Merck Index 14,3886
Solubility Information Insoluble in water.
Optical Rotation −107° (c=1 in Methanol/Dichloromethane 1:9)
Formula Weight 588.56
Physical Form Powder
Chemical Name or Material Etoposide

RUO – Research Use Only

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