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Tocris Bioscience™ Emetine dihydrochloride

Product Code. 18729416
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50 mg
Unit Size:
50mg
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18729416 50 mg 50mg
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Product Code. 18729416 Supplier Tocris Bioscience™ Supplier No. 7342/50

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Description

RNA polymerase inhibitor; inhibits replication of a broad range of RNA and DNA viruses, including SARS-CoV-2 and Zika

Emetine is a RNA polymerase inhibitor. It inhibits SARS-CoV-2 replication (EC50 = 460 nM) and in combination with Remdesivir (Cat. No.7226) synergistically inhibits the viral yield of SARS-CoV-2 by 64.9%. Emetine attenuates hCoV-OC43, hCoV-NL43, SARS-CoV, MERS-CoV, and MHV-A59 in vitro with EC50 values in the low micromolar range. It also inhibits replication of a broad range of RNA and DNA viruses, including influenza, ebolavirus and HIV-1. Emetine potently inhibits ZIKV replication in vitro (IC50 = 52.9 nm) and suppresses ZIKV viral load in vivo. Anti-inflammatory, antiviral, antimalarial, antibacterial and anti-amebic.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (2 S,3 R,11 bS)-3-Ethyl-1,3,4,6,7,11 b-hexahydro-9,10-dimethoxy-2-[[(1 R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2 H-benzo[a]quinolizine dihydrochloride
CAS 316-42-7
Quantity 50 mg
Target RNA/DNA Polymerase Inhibitors
Molecular Formula C29H40N2O40.2 HCl
Purity 0.98
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