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eIF3l Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Thermo Scientific PA551799
Additional Details : Weight : 0.02000kg
Description
Immunogen sequence: RMQKGDPQVY EELFSYSCPK FLSPVVPNYD NVHPNYHKEP FLQQLKVFSD EVQQQAQLST IRSFLKLYTT MPVAKLAGFL DLTEQEFRIQ LLVFKHKMKN LVWTSGISAL DGEFQSASEV DFYIDKDMIH IADTKVAR Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). [UniProt]Specifications
eIF3l | |
Polyclonal | |
Unconjugated | |
EIF3L | |
0610011H21Rik; 66 kDa tyrosine-rich heat shock protein; 67 kDa polymerase-associated factor; D15N1e; eIEF associated protein HSPC021; EIF3EIP; Eif3ip; EIF3L; EIF3S11; Eif3s6ip; Eukaryotic translation initiation factor 3 subunit 6-interacting protein; eukaryotic translation initiation factor 3 subunit E-interacting protein; Eukaryotic translation initiation factor 3 subunit L; eukaryotic translation initiation factor 3, subunit 6 interacting protein; eukaryotic translation initiation factor 3, subunit L; HSP-66Y; HSPC021; HSPC025; MSTP005; Paf67 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
51386 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q9Y262 | |
EIF3L | |
Recombinant protein corresponding to Human eIF3l | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only