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  4. Invitrogen™ Human EIF2AK1 (HRI), GST Tag Recombinant Protein

Invitrogen™ Human EIF2AK1 (HRI), GST Tag Recombinant Protein

Product Code. 10646075
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Quantity:
10 μg
Unit Size:
Each
This item is not returnable. View return policy

For Research Use Only. All usage must comply with product instructions.

Product Code. 10646075

Brand: Invitrogen™ PV5856

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This item is not returnable. View return policy

For Research Use Only. All usage must comply with product instructions.

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length.

EIF2AK1 (HRI) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK1, signaling is initiated by low levels of heme. The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands and kinase activity is induced by low levels of heme and inhibited by the presence of heme.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9BQI3
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM tris with no preservative
Gene ID (Entrez) 27102
Molecular Weight (g/mol) 98.6 kDa
Name Human EIF2AK1 (HRI), GST Tag
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1; eukaryotic translation initiation factor 2-alpha kinase 1; HCR; he; heme regulated initiation factor 2 alpha kinase; heme sensitive initiation factor 2a kinase; heme-controlled repressor; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; heme-regulated initiation factor 2-alpha kinase; heme-regulated repressor; hemin-sensitive initiation factor 2a kinase; hemin-sensitive initiation factor 2-alpha kinase; Hri; KIAA1369; PRO1362
Common Name HRI
Gene Symbol EIF2AK1
KinaseFamily PEK Kinase Family
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Sequence Full length
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Assay Entry Biochemical terbium phospho-specific activity
Kinase Group Ser⁄Thr Kinases: Other
Shipping Condition Dry Ice
System Compatibility LanthaScreen™
Tag Position N-Terminal
Target Entry EIF2AK1
Target Gene EIF2AK1
Expression System Baculovirus
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Full Length
Form Liquid
Protein Subtype Serine/Threonine Kinases
Research Category Signal Transduction
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