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Invitrogen™ EID1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5115165
This item is not returnable.
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Description
Antibody detects endogenous levels of total EID1.
E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.
Specifications
| EID1 | |
| Polyclonal | |
| Unconjugated | |
| EID1 | |
| 21 kDa pRb-associated protein; 2610002K20Rik; C15orf3; CREBBP/EP300 inhibitor 1; CREBBP/EP300 inhibitory protein 1; CRI1; E1A-like inhibitor of differentiation 1; EID; eid1; EID-1; EP300 interacting inhibitor of differentiation 1; EP300-interacting inhibitor of differentiation 1; IRO45620; NB4 apoptosis related protein; ORF12; PNAS-22; PTD014; Rb- and p300-binding protein EID-1; RBP21; retinoblastoma protein-associated protein; RGD1562702 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 23741 | |
| -20°C | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide | |
| Q9Y6B2 | |
| EID1 | |
| A synthesized peptide derived from human EID1(Accession Q9Y6B2), corresponding to amino acid residues K72-Y122. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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