missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. Invitrogen™ Ebdarokimab Recombinant Monoclonal Antibody

Invitrogen™ Ebdarokimab Recombinant Monoclonal Antibody

Product Code. 30282380
Change view
Click to view available options
Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
30282380 1 mg 1mg
30282718 100 μg 100µg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 30282380 Supplier Invitrogen™ Supplier No. MA559264

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Recombinant Monoclonal Antibody

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

Ebdarokimab, also known as AK101, is a monoclonal antibody that targets interleukin-12 (IL-12) and interleukin-23 (IL-23), two cytokines implicated in the inflammatory response associated with plaque psoriasis. Interleukin-12 subunit beta (IL-12b), also known as IL-12p40, is a crucial component of the heterodimeric cytokine IL-12 and IL-23. The IL-12b gene is located on chromosome 5q31-33 and encodes for a 40 kDa protein. IL-12 is composed of two subunits, p35 and p40, while IL-23 is composed of p19 and the shared p40 subunit. The IL-12b protein has a four-helix bundle structure, homologous to other members of the hematopoietin superfamily. Functionally, IL-12b plays a significant role in immune responses by promoting the differentiation of naive T cells into Th1 cells and enhancing the cytotoxic activity of natural killer (NK) cells. It is essential in the immune system's response to intracellular pathogens. Dysregulation of IL-12b has been implicated in various autoimmune diseases and cancers, making it a target for therapeutic interventions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ebdarokimab Humanized
Applications ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
Classification Recombinant Monoclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
Host Species Human
Purification Method Protein A
Quantity 1 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.