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  6. Invitrogen™ Ebdarokimab Recombinant Monoclonal Antibody

Invitrogen™ Ebdarokimab Recombinant Monoclonal Antibody
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Product Code. 30282718
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
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Product Code. Quantity unitSize
30282718 100 μg 100µg
30282380 1 mg 1mg
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Product Code. 30282718 Supplier Invitrogen™ Supplier No. MA559263

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Description

Recombinant Monoclonal Antibody

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

Ebdarokimab, also known as AK101, is a monoclonal antibody that targets interleukin-12 (IL-12) and interleukin-23 (IL-23), two cytokines implicated in the inflammatory response associated with plaque psoriasis. Interleukin-12 subunit beta (IL-12b), also known as IL-12p40, is a crucial component of the heterodimeric cytokine IL-12 and IL-23. The IL-12b gene is located on chromosome 5q31-33 and encodes for a 40 kDa protein. IL-12 is composed of two subunits, p35 and p40, while IL-23 is composed of p19 and the shared p40 subunit. The IL-12b protein has a four-helix bundle structure, homologous to other members of the hematopoietin superfamily. Functionally, IL-12b plays a significant role in immune responses by promoting the differentiation of naive T cells into Th1 cells and enhancing the cytotoxic activity of natural killer (NK) cells. It is essential in the immune system's response to intracellular pathogens. Dysregulation of IL-12b has been implicated in various autoimmune diseases and cancers, making it a target for therapeutic interventions.
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Specifications

Antigen Ebdarokimab Humanized
Applications ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
Classification Recombinant Monoclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
Host Species Human
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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