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E2F1 Monoclonal Antibody (KH95), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA514344
Additional Details : Weight : 0.01000kg
Description
MA5-14344 targets E2F-1 Transcription Factor in gel shift, immunofluorescence, immunohistochemistry (paraffin), immunoprecipitation, and Western blot applications and shows reactivity with Human and mouse samples. The MA5-14344 immunogen is recombinant human E2F-1 protein.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.Specifications
E2F1 | |
Monoclonal | |
0.4 mg/mL | |
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4 | |
Q01094, Q61501 | |
E2F1 | |
Recombinant human E2F-1 protein | |
500 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG2a κ |
Gel Shift, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
KH95 | |
Unconjugated | |
E2F1 | |
E2F transcription factor 1; E2F1; E2F-1; mKIAA4009; PBR3; PRB-binding protein E2F-1; RBAP1; RBAP-1; RBBP3; RBBP-3; RBP3; Retinoblastoma-associated protein 1; retinoblastoma-binding protein 3; Transcription factor E2F1 | |
Mouse | |
Protein A | |
RUO | |
13555, 1869 | |
4° C | |
Liquid |