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Dovitinib, MedChemExpress

Product Code. 16401336
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Product Code. 16401336

Brand: Medchem Express HY50905

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Description

MedChemExpress Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC50s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, CSF-1R, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively. Dovitinib has potent antitumor activity.

Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC50s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, CSF-1R, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively. Dovitinib has potent antitumor activity.

Specifications

Chemical Name or Material Dovitinib
CAS 405169-16-6
Color Yellow
Purity Grade Notes Research
Molecular Formula C21H21FN6O
Quantity 200 mg
Synonym CHIR-258 TKI258
Solubility Information DMSO : 25 mg/mL (63.71 mM; Need ultrasonic and warming)
SMILES O=C1NC(C=CC=C2F)=C2C(N)=C1C3=NC4=CC=C(N5CCN(C)CC5)C=C4N3
Molecular Weight (g/mol) 392.43
Formula Weight 392.43
Percent Purity 99.48%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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