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Doramapimod, MedChemExpress

Product Code. 16480966
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Code produit 16480966 Fournisseur Medchem Express Code fournisseur HY10320

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Description

MedChemExpress Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhibits B-Raf with an IC50 of 83 nM.

Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhibits B-Raf with an IC50 of 83 nM.

Spécification

Chemical Name or Material Doramapimod
CAS 285983-48-4
Color Off-White
Purity Grade Notes Research
Molecular Formula C31H37N5O3
Quantity 200 mg
Synonym BIRB 796
Solubility Information DMSO : 125 mg/mL (236.89 mM; Need ultrasonic) ∣Ethanol : 33.33 mg/mL (63.17 mM; Need ultrasonic)
SMILES O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3
Molecular Weight (g/mol) 527.66
Formula Weight 527.66
Percent Purity 99.6%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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