missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Biochemical Reagents
  4. Proteins and Derivatives
  5. Native Proteins and Derivatives
  6. Invitrogen™ Human DNA-PK Native Protein

Invitrogen™ Human DNA-PK Native Protein

Product Code. 15117975
Click to view available options
Quantity:
10 μg
100 μg
Unit Size:
100µg
10µg
This item is not returnable. View return policy

For Research Use Only. All usage must comply with product instructions.

Product Code. 15117975

Brand: Invitrogen™ PR9107A

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

For Research Use Only. All usage must comply with product instructions.

Description

Native Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Native human protein purified from MOLT-4 cells. No special measures were taken to activate this kinase. Protein Form: Full Length.

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P78527
Concentration Conc. Not Determined
For Use With (Application) Kinase Assay
Formulation 25mM HEPES with 1mM DTT, 0.2mM EDTA, 10% glycerol, 50mM KCl, 10mM MgCl2 and no preservative; pH 7.5
Gene ID (Entrez) 5591
Molecular Weight (g/mol) 600 kDa
Name Human DNA-PK
pH Range 7.5
Quantity 100 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
Common Name DNA-PK
Gene Symbol PRKDC
KinaseFamily PIKK Kinase Family
Product Type Protein
Conjugate Unconjugated
Species Human
Sequence Full length
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Kinase Group Ser⁄Thr Kinases: Atypical
Shipping Condition Dry Ice
Protein Family Kinases & Inhibitors
Protein Form Full Length
Form Liquid
Research Category Signal Transduction
Show More Show Less
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.