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DIO1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Thermo Scientific PA562085
Additional Details : Weight : 0.02000kg
Description
Immunogen sequence: PHPSQFETAR GPHPNQFEGP RGQAPNFMPG PRGIQPQQFE DQRVHSPPRF TNQRAPAPLQ FGGLRGSAPF SEKNEQTPSR FHFQGQ Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 79%.
The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.Specifications
DIO1 | |
Polyclonal | |
Unconjugated | |
Dio1 | |
5DI; D1; deiodinase, iodothyronine type I; deiodinase, iodothyronine, type I; Dio1; DIOI; hDido1; iodothyronine deiodinase type 1; ITDI1; thyroxine 5'-deiodinase; thyroxine deiodinase; thyroxine deiodinase type I (selenoprotein); thyroxine deiodinase, type I; TXDI1; Type 1 DI; type I iodothyronine deiodinase; Type-I 5'-deiodinase | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
1733 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry, Western Blot | |
0.5 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
P49895 | |
Dio1 | |
Recombinant protein corresponding to Human DIO1 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only