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STEMCELL Technologies Dabrafenib

Product Code. 17190162
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10 mg
Unit Size:
10mg
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17190162 10 mg 10mg
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Product Code. 17190162 Supplier STEMCELL Technologies Supplier No. 73072
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Estimated Shipment: 16-09-2026
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Descripción

MEK/ERK pathway inhibitor; Inhibits B-RAF V600E

  • Dabrafenib is a reversible, selective, and ATP-competitive inhibitor of B-RAF with higher potency towards V600E mutant B-RAF over wild-type B-RAF or C-RAF, with IC50 values of 0.8, 3.2 and 5 nM, respectively (Laquerre et al.; Menzies et al.)
  • Decreases ERK phosphorylation and inhibits cell proliferation in cells expressing the B-RAF mutation V600E
  • Prevents tumor growth in mouse xenograft models of B-RAF(V600E) human melanoma and colon cancer (Rheault et al.)
  • Alleviates acetaminophen-induced liver injury through distinct nanomolar inhibition of receptor-interacting protein (RIP3) in mice (Li et al.)

Especificaciones

CAS 1195765-45-7
Synonym GSK 2118436; Dabarefenib
Quantity 10 mg
Molecular Formula C23H20F3N5O2S2
Purity ≥98%
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