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Copanlisib, MedChemExpress

Product Code. 16472567
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Product Code. 16472567

Brand: Medchem Express HY15346

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Description

MedChemExpress Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity.

Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity.

Specifications

Chemical Name or Material Copanlisib
CAS 1032568-63-0
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C23H28N8O4
Quantity 50 mg
Synonym BAY 80-6946
Solubility Information 1M HCl : 100 mg/mL (208.11 mM; Need ultrasonic) ∣DMSO : 1 mg/mL (2.08 mM; Need ultrasonic) ∣H2O : 0.67 mg/mL (1.39 mM; Need ultrasonic)
SMILES O=C(C1=CN=C(N)N=C1)NC2=NC3=C(OC)C(OCCCN4CCOCC4)=CC=C3C5=NCCN25
Molecular Weight (g/mol) 480.52
Formula Weight 480.52
Percent Purity 98.02%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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