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Invitrogen™ CNOT7 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marque: Invitrogen™ PA531139
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Description
Recommended positive controls: U87-MG. Predicted reactivity: Human (99%), Mouse (99%), Rat (99%), Zebrafish (94%), Xenopus laevis (95%), Chicken (99%), Rhesus Monkey (99%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
CNOT7 (CCR4-NOT transcription complex subunit 7) has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. CNOT7 is a catalytic component of the CCR4-NOT complex, which is one of the major cellular mRNA deadenylases, and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation, and general transcription regulation. During miRNA-mediated repression, the complex seems to act as a transcriptional repressor during translational initiation, as well. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT7 associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Spécification
| CNOT7 | |
| Polyclonal | |
| Unconjugated | |
| CNOT7 | |
| AU022737; BTG1-binding factor 1; CAF1; CAF-1; Caf1a; carbon catabolite repressor protein (CCR4)-associative factor 1; catabolite repressor protein (CCR4)-associative factor 1; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 7; CCR4-NOT transcription complex subunit-like protein; CCR4-NOT transcription complex, subunit 7; CNOT7; fd59c07; fj07d05; hCAF-1; hypothetical protein LOC508055; Pop2; POP2 homolog; wu:fd59c07; wu:fj07d05; zgc:153168 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 29883 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 0.84 mg/mL | |
| 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
| Q9UIV1 | |
| CNOT7 | |
| Recombinant protein encompassing a sequence within the center region of human CNOT7. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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