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  7. Chloroquine diphosphate salt, 98%

Chloroquine diphosphate salt, 98%

Product Code. 15466399
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Product Code. 15466399 Supplier Thermo Scientific Alfa Aesar Supplier No. J64459.22
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Description

Chloroquine diphosphate salt, CAS # 50-63-5, is a member of the quinolone family that is considered to be a DNA intercalator. It shows anti-malarial, anti-inflammatory, and anti-filaricides activities. | CAS: 50-63-5 | C18H32ClN3O8P2 | 515.86 g/mol

Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 μM.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Chloroquine diphosphate salt is a DNA intercalator that shows anti-malarial and anti-inflammatory activities.
  • It has been described that this compound interferes with the biosynthesis of nucleic acids, suggesting a cellular mechanism of action

Applications

  • Chloroquine diphosphate salt is used as a DNA intercalator to dissociate antigen-antibody complexes without denaturing red blood cell antigens
  • This compound shows antimalarial activity against Plasmodium falciparum, except against chloroquine-resistant strains. It has been used in in vitro antiplasmodial assays. In parasites, the mechanism of action remains unclear, but this compound can inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemozoin, resulting in the accumulation of toxic heme within the parasite.
  • It shows very high anti-viral activity against NiV but lower activity against other viruses at concentrations lower than 20 μM
  • Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs
  • Chloroquine diphosphate salt has been used in autophagy inhibition studies
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 50-63-5
Molecular Formula C18H32ClN3O8P2
Molecular Weight (g/mol) 515.86
MDL Number MFCD00069852
InChI Key QKICWELGRMTQCR-UHFFFAOYNA-N
Synonym chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine
PubChem CID 64927
SMILES OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1

Specifica

Melting Point 213°C to 216°C
Color White
Quantity 100 g
Beilstein 4223142
Merck Index 14,2163
Solubility Information Soluble in water
IUPAC Name 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid
Formula Weight 515.87
Percent Purity 98%
Physical Form Powder
Chemical Name or Material Chloroquine diphosphate salt
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