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DiscoverX ChemiScreen™ PTH2 Parathyroid Hormone Receptor Stable Cell Line

Product Code. 17335319
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17335319

Brand: DiscoverX HTS173C

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This item is not returnable. View return policy

Description

The ChemiScreen™ PTH2 Parathyroid Hormone Receptor Stable Cell Line measures PTH2R (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiScreen™ PTH2 Parathyroid Hormone Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. parathyroid hormone) based activation of PTH2R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTH2R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of PTH2R , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Calcium Flux
Cell Line Chem-1
For Use With (Application) Cell Lines
Primary Agonist TIP 39, Tuberoinfundibular Neuropeptide
Quantity 2 Vials
Target Entry PTH2R
Accession Number AY497546
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