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  6. CHCHD6 Mouse anti-Human, Clone: 2A11E9, Proteintech

CHCHD6 Mouse anti-Human, Clone: 2A11E9, Proteintech

Product Code. 16808625 Shop All Proteintech Products
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20 μL
150 μL
Unit Size:
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20µL
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16808625 20 μL 20µL
16898615 150 μL 150µL
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Product Code. 16808625 Supplier Proteintech Supplier No. 665971IG20UL

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Description

Mouse Monoclonal Antibody

CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.

Specifications

Antigen CHCHD6
Applications Western Blot
Classification Monoclonal
Clone 2A11E9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene CHCHD6
Gene Accession No. Q9BRQ6
Gene Alias CHCHD6
Gene Symbols CHCHD6
Host Species Mouse
Immunogen CHCHD6 Fusion Protein Ag14700
Purification Method Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84303
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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