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STEMCELL Technologies Chaetocin

Product Code. 17100252
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500 μg
Unit Size:
500µg
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17100252 500 μg 500µg
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Product Code. 17100252 Supplier STEMCELL Technologies Supplier No. 73592

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Description

Epigenetic modifier; Inhibits histone methyltransferase SU(VAR)3-9

  • Chaetocin is a fungal mycotoxin, originally produced by Chaetomium species, that inhibits the lysine-specific histone methyltransferases (HMTs) SU(VAR)3-9 (IC50 = 0.8 μM)
  • HMTs are responsible for methylation of histones, thereby affecting heterochromatinization
  • Chaetocin is also known to inhibit G9a and DIM5 (IC50 = 2.5 μM and 3 μM respectively; Cherblanc et al.; Greiner et al.) Chaetocin also acts as a competitive substrate and inhibitor of the central oxidative stress remediation enzyme thioredoxin reductase-1 (TrxR1; Km = 4.6 μM) more potently than glutathione reductase or thioredoxin (Tibodeau et al.)
  • Induces cellular oxidative stress, selectively killing cancer cells and rapidly-proliferating primary cells (Isham et al.; Spannhoff et al.)
  • Attenuates the growth of glioma xenografts accompanied by an increase in reactive oxygen species (ROS) production (Dixit et al.)

Specifications

CAS 28097-03-2
Synonym Chaetocin A
Quantity 500 μg
Molecular Formula C30H28N6O6S4
Purity ≥95%
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