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Ceritinib dihydrochloride, MedChemExpress

Product Code. 16436728
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Product Code. 16436728

Brand: Medchem Express HY15656A

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Description

MedChemExpress Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib dihydrochloride (LDK378 dihydrochloride) also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib dihydrochloride (LDK378 dihydrochloride) shows great antitumor potency.

Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib dihydrochloride (LDK378 dihydrochloride) also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib dihydrochloride (LDK378 dihydrochloride) shows great antitumor potency.

Specifications

Chemical Name or Material Ceritinib dihydrochloride
CAS 1380575-43-8
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C28H38Cl3N5O3S
Quantity 10 mg
Synonym LDK378 dihydrochloride
Solubility Information DMSO : 100 mg/mL (158.46 mM; Need ultrasonic) ∣H2O : 10 mg/mL (15.85 mM; Need ultrasonic)
SMILES CC(C)OC1=CC(C2CCNCC2)=C(C)C=C1NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3.[H]Cl.[H]Cl
Molecular Weight (g/mol) 631.06
Formula Weight 631.06
Percent Purity 99.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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