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CD7 Monoclonal Antibody (4H9), APC, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
99.25 € - 291.00 €
Specifications
Antigen | CD7 |
---|---|
Clone | 4H9 |
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15537866
|
Affymetrix eBioscience
17-0078-42 |
100 Tests |
291.00 €
100 tests |
Estimated Shipment: 08-05-2024 Log in to see stock. |
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15527866
|
Affymetrix eBioscience
17-0078-41 |
25 Tests |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: This 4H9 monoclonal antibody reacts with human CD7 (also known as Leu-9 or gp40), a 40-kDa transmembrane glycoprotein belonging to the immunoglobulin superfamily. This molecule is expressed on peripheral blood T lymphocytes and natural killer cells, as well as on lymphoid and myeloid lineage precursors during adult hematopoiesis. Capable of providing a costimulatory signal and associating with CD3 and CD45, CD7 is involved in T cell activation. CD7 has also been detected on numerous T cell-derived leukemias and lymphomias. In fact, because CD7 expression is greater on CD4+ T cells in classical Hodgkin's lymphoma than in benign reactive lymph adenopathy, this molecule may be used as a diagnostic for Hodgkin's lymphoma. Blocking assays demonstrate that this clone recognizes the same epitope as clone 124-1D1. Applications Reported: This 4H9 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 4H9 antibody has been pre-titrated and tested by flow cytometric analysis on normal human peripheral blood cells. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.
CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily. CD7 contains N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxy-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. Further, CD7 is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. Expression of CD7 is an important marker used in leukemia diagnostics.Specifications
CD7 | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
P09564 | |
CD7 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
CD7 |
4H9 | |
Flow Cytometry | |
APC | |
Mouse | |
Human | |
924 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.