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  6. CD49f (Integrin α6) Rat, anti-Mouse, Pacific Blue, Clone: GoH3, STEMCELL Technologies

CD49f (Integrin α6) Rat, anti-Mouse, Pacific Blue, Clone: GoH3, STEMCELL Technologies

Product Code. 17108701
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17108701 100 Tests 100 tests
17118701 25 Tests 25 tests
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Product Code. 17108701 Supplier Stemcell Technologies Supplier No. 60037PB

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Description

Rat Monoclonal Antibody

  • The GoH3 antibody reacts with CD49f (integrin α6), an ∼150 kDa transmembrane glycoprotein that associates non-covalently with CD29 (integrin β1) or CD104 (integrin β4) to form the heterodimeric receptors VLA-6 and α6β4, which bind the extracellular matrix protein laminin
  • CD49f is a disulfide-linked dimer comprising an ∼120 kDa heavy chain and an ∼30 kDa membrane-bound light chain
  • Splice variants exist, which affect the cytoplasmic domain of the protein
  • CD49f is expressed on the surface of T cells, monocytes, platelets, placental trophoblasts, epithelial cells, and endothelial cells
  • It is involved in cell adhesion and regulating signaling pathways involved in a variety of processes, including the activation and proliferation of T cells, and the differentiation and maintenance of stem cell pluripotency
  • CD49f is considered the most important marker for selecting mouse mammary stem and progenitor cells
  • The GoH3 antibody reacts with an extracellular epitope on CD49f

Specifications

Antigen CD49f (Integrin α6)
Applications Immunohistochemistry, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay
Classification Monoclonal
Clone GoH3
Conjugate Pacific Blue
Host Species Rat
Quantity 100 Tests
Primary or Secondary Primary
Target Species Baboon, Cynomolgus, Pig, Human
Isotype IgG2a κ
Cell Type Mammary Cells
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