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Invitrogen™ CD321 (F11R) Monoclonal Antibody (H202-106)
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Product Code. 16302474
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Quantity:
100 μg
Unit Size:
100µg
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16302474 100 μg 100µg
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Product Code. 16302474 Supplier Invitrogen™ Supplier No. MA528179

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Description

Rat Monoclonal Antibody

This antibody recognizes murine CD321, also known as junctional adhesion molecule 1 (JAM-1). CD321 is a 274 amino acid, single pass, type I transmembrane glycoprotein, which shares similarities with related proteins JAM-2 and JAM-3. CD321 is a multifunctional protein primarily expressed by platelets, endothelial and epithelial cells.

CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. CD321 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins. CD321 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact. CD321 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin. CD321 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD321 (F11R)
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation
Classification Monoclonal
Clone H202-106
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene F11r
Gene Accession No. O88792
Gene Alias 9130004G24; AA638916; BV11 antigen; CD321; ESTM33; F11 R; F11 receptor; F11 receptor/F11R; F11R; JAM; JAM1; JAM-1; JAMA; JAM-A; Jcam; Jcam1; junction cell adhesion molecule A; junction cell adhesion molecule1; junctional adhesion molecule 1; Junctional adhesion molecule A; KAT; Ly106; PAM-1; Platelet adhesion molecule 1; platelet F11 receptor; UNQ264/PRO301
Gene Symbols F11r
Host Species Rat
Immunogen MTE1/MTE2 stromal cell lines.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16456
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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