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Invitrogen™ CD31 Monoclonal Antibody (ER-MP12)
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Product Code. 11529682
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Quantity:
100 μg
Unit Size:
100µg
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11529682 100 μg 100µg
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Product Code. 11529682 Supplier Invitrogen™ Supplier No. MA140074

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Description

Rat Monoclonal Antibody

MA1-40074 detects CD31 from mouse samples. MA1-40074 reacts with an antigen present on cell subpopulations of adult mouse bone marrow, including pluripotent hematopoietic stem cells. MA1-40074 reacts with the major population of colony forming unit macrophage (CFU-M) precursor cells, with subpopulation of pre CFU-M and monoblasts, and with precursor cells of granulocytes. MA1-40074 has been successfully used in ELISA, immunohistochemistry (paraffin and frozen), immunoprecipitation, and flow cytometry applications. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting, working dilution is 1:50. The MA1-40074 immunogen is mouse PECAM-1/CD31. Suggested positive control: Macrophage cell line RMB-1.

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
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Specifications

Antigen CD31
Applications ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Monoclonal
Clone ER-MP12
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and 0.02% sodium azide
Gene Pecam1
Gene Accession No. Q08481
Gene Alias C85791; CD31; CD31 antigen; CD31, PECAM-1; CD31/EndoCAM; endoCAM; GPIIA'; I79_008304; PECA1; Pecam; PECAM1; Pecam-1; platelet and endothelial cell adhesion molecule 1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); platelet/endothelial cell adhesion molecule 1; type I transmembrane endothelial adhesion molecule
Gene Symbols Pecam1
Host Species Rat
Immunogen Murine macrophage precursor hybrid W1C3cell hybrid.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18613
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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