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CD274 (PD-L1, B7-H1) Monoclonal Antibody (1-111A), eBioscience™, Invitrogen™
Rat Monoclonal Antibody
110.00 € - 223.00 €
Specifications
Antigen | CD274 (PD-L1, B7-H1) |
---|---|
Clone | 1-111A |
Concentration | 0.5 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15238297
|
Affymetrix eBioscience
14-9971-82 |
100 μg |
223.00 €
100µg |
Estimated Shipment: 19-06-2024 Log in to see stock. |
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15228297
|
Affymetrix eBioscience
14-9971-81 |
50 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: The 1-111A monoclonal antibody reacts with mouse B7-H1, also known as PD-L1. B7-H1, a member of the B7 family, has a predicted molecular weight of approximately 40 kDa and belongs to the Ig superfamily. B7-H1 is expressed on a majority of leukocytes including T, B, NK and DC. B7-H1 is a ligand for PD-1. Interaction of PD-1 with either PD-L1 (B7-H1) or PD-L2 (B7-DC) results in inhibition of T and B cell responses. Preliminary testing suggests that 1-111A and MIH5 (Cat. No. 14-5982) cross-block each other. Applications Reported: The 1-111A antibody has been reported for use in flow cytometric analysis. Applications Tested: The 1-111A antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.Specifications
CD274 (PD-L1, B7-H1) | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
Q9EP73 | |
Cd274 | |
Primary | |
4° C | |
Cd274 |
1-111A | |
Flow Cytometry | |
Unconjugated | |
Rat | |
Mouse | |
60533 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.