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Invitrogen™ CD230 (PrP) Monoclonal Antibody (ROS-1H9)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA528325
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Description
Mouse anti Sheep CD230 (Prpsc) antibody, clone ROS-1H9 recognizes the prion disease form of prion protein known as CD230.
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
Specifications
| CD230 (PrP) | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with <0.1% sodium azide | |
| P23907 | |
| PRNP | |
| A truncated form of recombinant Ovine PRP spanning residues aa94 - aa233. | |
| 100 μg | |
| Primary | |
| Sheep | |
| Antibody | |
| IgG2a |
| Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot | |
| ROS-1H9 | |
| Unconjugated | |
| PRNP | |
| AA960666; AI325101; Alternative prion protein; alternative prion protein; major prion protein; AltPrP; ASCR; BSE; CD230; CD230 antigen; CJD; GSS; KURU; major prion protein; major prion protein; alternative prion protein; major scrapie-associated fibril protein 1; MGC26679; p27-30; PK resistant core; prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein precursor; prion protein precursor PrP; prion protein PrP; prion protein variant a; prion protein variant b; prion protein, PrP; prion protein, structural; prion-related protein; PRIP; Prn; Prn-i; Prnp; Prn-p; PrP; PrP>C>; PrP27-30; PrP33-35C; PrPc; PrPSc; Sinc; SIP; TSE | |
| Mouse | |
| Protein G | |
| RUO | |
| 493887 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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