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CCT128930, MedChemExpress

Product Code. 16465598
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Product Code. 16465598

Brand: Medchem Express HY13260

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Description

MedChemExpress CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC50=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). Antitumor activity.

CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC50=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). Antitumor activity.

Specifications

Chemical Name or Material CCT128930
CAS 885499-61-6
Color Off-White
Purity Grade Notes Research
Molecular Formula C18H20ClN5
Quantity 10 mg
Solubility Information DMSO : 33.33 mg/mL (97.50 mM; ultrasonic and warming and heat to 60°C)
SMILES ClC1=CC=C(C=C1)CC2(CCN(CC2)C3=NC=NC4=C3C=CN4)N
Molecular Weight (g/mol) 341.84
Formula Weight 341.84
Percent Purity 98.07%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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