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  6. Thermo Scientific Chemicals Calpain Inhibitor II, 95+%

Thermo Scientific Chemicals Calpain Inhibitor II, 95+%

Product Code. 15494869
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Product Code. 15494869 Supplier Thermo Scientific Chemicals Supplier No. J62491.MB
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Description

An inhibitor of calpains I and II

ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 136632-32-1
Molecular Formula C19H35N3O4S, C19H35N3O4S
Synonym N-Ac-Leu-Leu-Methioninal; ALLM

Specifications

Quantity 25 mg
Description White
Content And Storage -30°C to -10°C
For Use With (Application) An inhibitor of calpains I and II
Formula Weight 401.60g/mol
Solubility Soluble in ethanol at 20mg/ml
Product Type Signal Transduction Reagent
Form Powder
Beilstein 7693643
InChI Key RJWLAIMXRBDUMH-UHFFFAOYNA-N
SMILES CSCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(C)=O)C=O
IUPAC Name 2-acetamido-4-methyl-N-(3-methyl-1-{[4-(methylsulfanyl)-1-oxobutan-2-yl]carbamoyl}butyl)pentanamide
Molecular Weight (g/mol) 401.57
Assay ≥95%
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