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  6. C1orf106 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

C1orf106 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16861095 Shop All Proteintech Products
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150 μL
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20µL
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16861095 150 μL 150µL
16871095 20 μL 20µL
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Product Code. 16861095 Supplier Proteintech Supplier No. 215061AP150UL

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Description

Rabbit Polyclonal Antibody

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.

Specifications

Antigen C1orf106
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene C1orf106
Gene Accession No. Q3KP66, Q7TN12
Gene Alias C1orf106
Gene Symbols C1orf106, Inava
Host Species Rabbit
Immunogen C1orf106 Fusion Protein Ag15987
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 289399, 55765, 67313
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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